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In Vitro Antimicrobial Properties of Coconut Oil on Candida Species in Ibadan, Nigeria.

In Vitro Antimicrobial Properties of Coconut Oil on Candida Species in Ibadan, Nigeria.

Ogbolu DO, Oni AA, Daini OA, Oloko AP.

Department of Medical Microbiology and Parasitology, University College Hospital, Ibadan, Nigeria.

J Med Food. 2007 Jun;10(2):384-7.

Virgin Coconut Oil Shows Antifungal Potential Against Drug-Resistant Candida Species 

In vitro Study Suggests Coconut Oil Could Be an Effective Natural Alternative to Antifungal Drugs 

With the rise of antimicrobial resistance and a limited supply of effective fungicidal treatments, researchers are turning to natural alternatives to combat persistent fungal infections. A recent study conducted at the University College Hospital, Ibadan, Nigeria, evaluated the antifungal properties of virgin coconut oil against drug-resistant Candida species commonly found in clinical settings. 

Candida Species and the Growing Threat of Resistance 

In 2004, researchers collected 52 clinical isolates of Candida species from the hospital’s Medical Microbiology Laboratory. These included: 

  •  Candida albicans (17 isolates) – the most common pathogen 
  •  Candida glabrata (9) 
  •  Candida tropicalis (7) 
  •  Candida parapsilosis (7) 
  •  Candida stellatoidea (6) 
  •  Candida krusei (6)

Virgin Coconut Oil vs. Fluconazole: Antifungal Activity Compared 

The study compared the antifungal efficacy of virgin coconut oil and fluconazole using the agar-well diffusion method. Here’s what the researchers found: 

  •  Virgin coconut oil demonstrated strong antifungal activity, especially against Candida albicans, which showed 100% susceptibility with a minimum inhibitory concentration (MIC) of 25% (1:4 dilution).
  •  In contrast, fluconazole showed 100% susceptibility at a higher MIC of 64 µg/mL. 
  •  Candida krusei, a known fluconazole-resistant strain, also showed resistance to coconut oil, requiring a 100% (undiluted) concentration for inhibition. 
  •  Fluconazole was ineffective against C. krusei with an MIC of >128 µg/mL.

Key Findings and Implications 

  • Virgin coconut oil exhibited antifungal activity against multiple Candida species, including some fluconazole-resistant strains. 
  •  Its natural composition of medium-chain fatty acids, particularly lauric acid, is believed to disrupt fungal cell membranes. 
  •  The results support the use of natural antifungal agents like coconut oil in treating cutaneous and mucosal Candida infections, especially in resource-limited settings or where drug resistance is prevalent.

Conclusion: Coconut Oil as a Promising Antifungal Treatment 

 This study highlights virgin coconut oil as a promising alternative to conventional antifungal drugs. Its effectiveness against Candida albicans and other species, even those with known resistance to fluconazole, suggests that natural therapies could play a vital role in managing fungal infections in the face of rising drug resistance. 

 Further clinical studies are recommended to validate its use in human therapy, but the antifungal potential of coconut oil offers hope for safer, affordable, and accessible treatment options.

Scientific Articles antifungal candida resistance coconut