You are using an outdated browser. Please upgrade your browser or use Google Chrome to improve your experience. Close
Dysbiosis can be defined as a perforated hind gut, an excessively permeable intestine or a condition of erosion and ulceration of the gastrointestinal tract.
Under normal conditions, when animals receive a balanced diet, the intestinal micro-organisms attempt to live in balance with the host animal, termed symbiosis. In contrast, dysbiosis is when there is overgrowth of these normal organisms, caused by an oversupply of digestible nutrients (sugars and starch), that allow the organisms to multiply rapidly. The over-production of organisms is thought to cause an excessively permeable intestine, and/or a perforated hindgut, termed "leaky gut syndrome". Microbial population upsets, and subsequent damage to the intestinal mucosa, allows leakage of sugar molecules, bacteria and pathogens into the bloodstream causing it to become toxic.
Examples of Dysbiosis include Candidiasis caused by Candida albicans in humans, and Enterotoxaemia (pulpy kidney) caused by Clostridium perfringens in cattle. In cattle, pulpy kidney disease will cause death within hours of feeding new, highly digestible pastures and grain.
In horses, the absorption of glucose into the cell is facilitated by insulin released from the pancreas. When higher than normal levels of glucose are present, increased amounts of insulin are released, to increase the uptake of glucose into the cell. When horses are fed high levels of sugars and starch (NSC) that exceed the normal digestive capacity of the gut, the excess NSC is used as a food source by the resident microbial organisms, causing proliferation of these organisms, possible damage to the gut mucosa, and increased glucose absorption.
The flooding of excess glucose into the blood due to dysbiosis results in "rushes" of insulin. High insulin levels can either cause a;
The high blood sugar also stimulates the adrenal gland to increase cortisol production, catabolising proteins and inflaming connective tissue in the hooves, causing laminitis and founder.
Dysbiosis also poses a large health risk at it allows for the passage of harmful pathogens and toxins to enter directly into the bloodstream, as evidenced by the sudden death of cattle to Cl. perfringens
Dysbiosis also can also cause a general build up of lactic acid interfering with performance, immunity, muscle function and metabolism. Dysbiosis has a detrimental effect on the liver as it is under challenge to filter the toxins from the blood, such that the filtering capacity may be compromised, allowing circulation of free radicals that may exacerbate chronic disease, e.g. laminitis.
Feeding high levels of sugars and starch (NSC's) to horses and ponies increases the chances of leaky gut or dysbiosis, especially if more than 50% of the ration is made up of sweet feed (i.e. grain and molasses). The increased chance of leaky gut is due to the absorption of high levels of glucose and the production of high levels of insulin. Rapid changing of feed rations or diets may impact the gut flora and result in dysbiosis.
Possible feeding strategies to avoid dysbiosis include;
