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Xanthorrhizol: a review of its pharmacological activities and anticancer properties

Xanthorrhizol: a review of its pharmacological activities and anticancer properties

Abstract 

Xanthorrhizol (XNT) is a bisabolane-type sesquiterpenoid compound extracted from Curcuma xanthorrhiza Roxb. 

It has been well established to possess a variety of biological activities such as; 

  • anticancer, 
  • antimicrobial, 
  • anti-inflammatory, 
  • antioxidant, 
  • antihyperglycemic, 
  • antihypertensive, 
  • antiplatelet, 
  • nephroprotective,
  •  hepatoprotective, 
  • estrogenic and 
  • anti-estrogenic effects. 

Since many synthetic drugs possess toxic side effects and are unable to support the increasing prevalence of disease, there is significant interest in developing natural products as new therapeutics. XNT is a very potent natural bioactive compound that could fulfil the current need for new drug discovery. Despite its importance, a comprehensive review of XNT's pharmacological activities has not been published in the scientific literature to date. Here, the present review aims to summarize the available information in this area, focus on its anticancer properties, and indicate the current status of the research. This helps facilitate an understanding of XNT's pharmacological role in drug discovery, suggesting areas where further research is required. Keywords: Xanthorrhizol, Curcuma xanthorrhiza Roxb.

Oon et al. Cancer Cell Int (2015) 15:100? DOI 10.1186/s12935-015-0255-4

Curcuma xanthorrhiza is a key ingredient in Turmericle and UlcaBuf


turmeric Xanthorrhizol Curcuma xanthorrhiza Roxb curcuma